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March 1978

Contact Dermatitis Due to Clindamycin

Arch Dermatol. 1978;114(3):446. doi:10.1001/archderm.1978.01640150082025

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To the Editor.—  Oral doses of clindamycin hydrochloride capsules (150 to 300 mg daily) are effective in the treatment of acne vulgaris.1,2 However, since ingestion of this drug can cause severe colitis, it probably should not be used as the drug of choice to treat acne vulgaris. Recently, clindamycin phosphate, which is used for intramuscular and intravenous use, has been used topically in a 1% solution for acne with good results.3,4 Clindamycin has also been applied topically for acne. I describe a case of contact dermatitis that was due to 1% clindamycin hydrochloride solution.

Report of a Case.—  A 33-year-old woman was seen on March 7, 1977, because of excoriated, pruritic acne lesions that involved her face. She had previously taken tetracycline hydrochloride by mouth and used benzoyl peroxide topically. Because these agents had not been helpful, her physician changed her therapy to 1% clindamycin hydrochloride diluted in

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