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April 1978

Dermatitis and Sézary's Cells

Author Affiliations

Rochester, Minn

Arch Dermatol. 1978;114(4):623. doi:10.1001/archderm.1978.01640160089032

To the Editor.—  Sézary's cells are characteristically found in the peripheral blood smears of patients with Sézary's syndrome and have been noted histologically in malignant, premalignant, and benign dermatoses.1,2 These cells also have been noted in the peripheral blood of patients with "pre-Sézary's erythroderma syndrome."3 However, we have found that a few Sézary's cells are commonly present in the peripheral blood of patients with generalized dermatitis of varied causes.When serial peripheral blood smears were taken from patients at the Mayo Clinic, who were hospitalized for exfoliative dermatitis, Sézary's cells amounted to 1% to 3% of the total cell count and were frequently found during the acute phase of the severe dermatitis. We found that Sézary's cells were no longer demonstrable when the dermatitis cleared; this also was noted in generalized contact dermatitis, atopic dermatitis, and exfoliative psoriasis.The graph of serial counts of Sézary's cells is characteristic