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May 1978

Origin of Familial Malignant Melanomas From Heritable Melanocytic Lesions: `The B-K Mole Syndrome'

Author Affiliations

From the Departments of Pathology and Dermatology, and the Fels Research Institute, Temple University School of Medicine, Philadelphia (Drs Clark and Ainsworth); the Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Md (Drs Reimer and Greene); and the Fox Chase Cancer Center, Philadelphia (Dr Mastrangelo).

Arch Dermatol. 1978;114(5):732-738. doi:10.1001/archderm.1978.01640170032006

• Distinctive melanocytic moles are described in 37 patients from six melanoma families. Among the family members examined by the authors, 15 of 17 patients with melanoma and 22 of 41 nonmelanoma relatives had the unique moles. The clinical and histological features of these moles have been designated the "B-K mole syndrome." The clinical features of the syndrome include the presence of < 10 to > 100 moles prominent on the upper trunk and extremities, and variability of mole size (5 mm to 15 mm), outline, and color combination. Histologically, B-K moles show atypical melanocytic hyperplasia, lymphocytic infiltration, delicate fibroplasia, and new blood vessels that occur within a compound nevus or de novo. The transformation of two B-K moles into malignant melanomas was documented photographically.

(Arch Dermatol 114:732-738, 1978)