[Skip to Navigation]
May 1978

Multiple Hamartoma Syndrome (Cowden's Disease)

Author Affiliations


From the Dermatology Service, Fitzsimons Army Medical Center, Denver. Dr Clemons is now with Second General Hospital, New York, and Dr Weber is now with Munson Army Hospital, Fort Leavenworth, Kan. Dr Nuss is in private practice.

Arch Dermatol. 1978;114(5):743-746. doi:10.1001/archderm.1978.01640170043008

• The four male patients with multiple hamartoma syndrome (Cowden's disease) in this report, have most of the previously reported findings associated with this syndrome and several important unreported findings that include multiple cutaneous trichilemmomas, cafe-au-lait spots, cutaneous squamous cell carcinoma, pathologic fracture, craniomegaly, probable malignant lung tumor, retinal glioma, drusens of the optic disk and retina, pseudotumor cerebri, mediastinal mass, and multiple small papillomatous lesions of the esophagus, stomach, and duodenum.

(Arch Dermatol 114:743-746, 1978)

Add or change institution