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May 1978

The Sézary Syndrome: A Case With Fetal-type Glycogen and Lymphocytic Lymphoma

Author Affiliations

From the Departments of Pathology (Dr Menefee), Hematology (Dr Zellner), and Dermatology (Dr Wright), College of Medicine, University of Cincinnati.

Arch Dermatol. 1978;114(5):772-774. doi:10.1001/archderm.1978.01640170072016

† A patient had Sézary syndrome and lymphocytic lymphoma. Cytoplasmic inclusions within the Sézary cells were demonstrated by histochemistry and electron microscopy to be composed of fetaltype glycogen. Results of tests for the presence of virus were negative. It is suggested that the Sézary cell represents a reversion of metabolic systems to more youthful types. Previously reported differences in diastase reactivity of the PAS-positive cytoplasmic inclusions are probably based on whether the glycogen is in fetal or mature configuration.

(Arch Dermatol 114:772-774, 1978)