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May 1978

Topical Sulfadiazine Silver for Bullous Pemphigoid

Arch Dermatol. 1978;114(5):803. doi:10.1001/archderm.1978.01640170097043

To the Editor.—  In the past year we have used sulfadiazine silver (Silvadene) for topical treatment of stubborn bullous pemphigoid lesions with very good results. Sulfadiazine silver is a water-miscible cream that has broad antimicrobial activity against Gram-negative and Gram-positive bacteria as well as yeast. It is supplied in 50- and 400-g jars.1We have been applying sulfadiazine silver twice daily following Burrow's compresses and are impressed with the superiority of this regimen compared with other topical treatments, such as gentian violet. All lesions that have been treated have healed exceedingly quickly with a minimum of secondary infection. In addition, we have had two patients with localized bullous pemphigoid for which systemic treatment was not indicated and treatment with sulfadiazine silver alone resulted in complete remission.The question arises whether the therapeutic effect of sulfadiazine silver is due to its broad antimicrobial activity or to a local effect of

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