• The records of ten patients with Lucio's phenomenon showed clinical and histopathological changes similar to those described by others. Lucio's phenomenon is a syndrome distinct from erythema nodosum leprosum as indicated by an absence of fever, leukocytosis and tenderness, a failure to respond to thalidomide, and a restriction to patients with diffuse nonnodular lepromatous leprosy. Lymphopenia associated with splenomegaly in three patients and glomerulonephritis in one patient were unexpected findings of unknown relevance.
(Arch Dermatol 114:1023-1028, 1978)
Rea TH, Levan NE. Lucio's Phenomenon and Diffuse Nonnodular Lepromatous Leprosy. Arch Dermatol. 1978;114(7):1023–1028. doi:10.1001/archderm.1978.01640190011004
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