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July 1978

Percutaneous Absorption in Experimental Epidermal Proliferation

Author Affiliations

From the Division of Dermatology, Scripps Clinic and Research Foundation, La Jolla, Calif (Dr Solomon), and the Department of Dermatology, University of Wisconsin School of Medicine, Madison (Dr Lowe). Dr Solomon is now with the University of Chicago.

Arch Dermatol. 1978;114(7):1029-1030. doi:10.1001/archderm.1978.01640190017005

• Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.

(Arch Dermatol 114:1029-1030, 1978)

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