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July 1978

Metastatic Renal Cell Carcinoma Resembling a Pyogenic Granuloma

Author Affiliations

From the Department of Dermatology, Baylor College of Medicine, Houston.

Arch Dermatol. 1978;114(7):1082-1083. doi:10.1001/archderm.1978.01640190066025

Compared with other solid neoplasms, cutaneous metastasis of renal cell carcinoma is not uncommon, and a dermal nodule may be the only clinical manifestation of a silent primary tumor. Because of exuberant vascularity, the lesion may be misdiagnosed as a benign vascular tumor.

We have observed a solitary cutaneous metastasis of occult renal cell carcinoma that resembled a pyogenic granuloma. Early diagnosis and expedient ablation of the stricken kidney was based on clinical awareness of the angiogenic impact of renal carcinoma and a healthy skepticism regarding ostensibly benign vascular lesions. This is a useful illustration of the diagnostic relevance of tumor-induced angiogenesis.

Report of a Case  A 63-year-old man had an asymptomatic, pedunculated crimson nodule on the chin. The initial clinical impression was pyogenic granuloma. The lesion was excised, and a histopathologic evaluation showed a wellcircumscribed intradermal nodule comprising nests and lobules of large, round cells with a pale, vacuolated