To the Editor.—
The treatment of recurrent herpes simplex is and has been varied. We have found a variation of an old remedy, repeated dabbing with a solution of epinephrine (adrenalin), to be clinically helpful.1 Patients are instructed to apply an aqueous solution of epinephrine (1:1,000) with a finger to the site of the earliest prodromal symptom, ie, itching, tingling, burning, or the early area of erythema. They are told to repeat this every 30 minutes or as frequently as necessary to maintain a blanch in that area during the first three to four hours. Caution is exercised to avoid the application of this to mucosal surfaces, especially in the elderly with cardiac problems.Among 12 patients who used the aqueous solution of epinephrine (1:1,000) during a two-year period, all reported immediate symptomatic relief. Nine stated that the use of epinephrine shortened the course of the process from onset of
Robinson JK, Spencer SK. Treatment of Recurrent Herpes Simplex. Arch Dermatol. 1978;114(7):1096–1097. doi:10.1001/archderm.1978.01640190074039
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