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August 1978

Coexistence of Bullous Pemphigoid and Systemic Lupus Erythematosus

Author Affiliations

From the Department of Microbiology, State University of New York at Buffalo (Drs Kumar and Beutner and Mr Binder), the Section of Dermatology, Department of Medicine, University of Kansas Medical Center, Kansas City (Dr Schotland), and the Department of Dermatology, Warsaw Academy of Medicine, Warsaw (Dr Chorzelski).

Arch Dermatol. 1978;114(8):1187-1190. doi:10.1001/archderm.1978.01640200041010

• A vesiculobullous eruption with clinical and histological features of bullous pemphigoid developed in a 28-year-old woman with proven systemic lupus erythematosus (SLE). Serum of this patient contained elevated titers of antinuclear antibodies but basement membrane antibodies could not be detected at first, though they did appear in blister fluid. Normal monkey skin explants cultured on this patient's sera gave positive direct immunofluorescence (IF) at the basement membrane zone (BMZ) for IgG deposits. The use of tissue culture methods may be helpful because of the capability of this test system to reveal the presence of the antibodies to the BMZ despite the presence of the antinuclear antibodies that appear to interfere with their demonstration in standard indirect IF tests.

(Arch Dermatol 114:1187-1190, 1978)