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August 1978

Cheilitis Granulomatosa: Successful Treatment With Combined Local Triamcinolone Injections and Surgery

Author Affiliations

From the Department of Oral Diagnosis, School of Dental Medicine, and the Department of Anatomic Pathology, School of Medicine, University of Connecticut, Farmington (Dr Krutchkoff), and the Department of Oral Maxillofacial Surgery, Louisiana State University Medical Center, New Orleans (Dr James).

Arch Dermatol. 1978;114(8):1203-1206. doi:10.1001/archderm.1978.01640200057015

• Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained in our case with local triamcinolone acetonide injections and surgery.

Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a series of triamcinolone injections. It was found that the injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect on granulomas with subsequent replacement by fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a second cheiloplastic procedure. We therefore recommend that patients with cheilitis granulomatosa who are receiving combined triamcinolonesurgical therapy continue to receive local triamcinolone injections after surgery in order to minimize the tendency for recurrence.

(Arch Dermatol 114:1203-1206, 1978)

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