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August 1978

Congenital Poikiloderma With Features of Hereditary Acrokeratotic Poikiloderma

Author Affiliations

From the Divisions of Dermatology, Department of Pediatrics (Drs Draznin and Esterly) and Department of Medicine (Dr Fretzin), and the Department of Pathology (Dr Fretzin), Michael Reese Hospital and Medical Center, Chicago. Dr Draznin is now with the University of Virginia School of Medicine, Charlottesville, and Dr Esterly is with Northwestern University Medical School, Chicago.

Arch Dermatol. 1978;114(8):1207-1210. doi:10.1001/archderm.1978.01640200061016

• An adolescent boy with a bizarre progressive poikiloderma had episodic acral blistering and the development of palmar and plantar keratosis suggestive of hereditary acrokeratotic poikiloderma. Growth and development had been normal. Vesicobullous lesions were said to be present at birth and during early infancy. No family members were similarly affected. Results of laboratory studies were normal. Histological sections of skin demonstrated epidermal atrophy in some areas, increased epidermal melanin fibrosis of the papillary dermis, and modest capillary proliferation.

(Arch Dermatol 114:1207-1210, 1978)

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