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September 1978

Levamisole Therapy in Atopic Dermatitis: Randomized Double-Blind Evaluation

Author Affiliations

From the University of Oregon Health Sciences Center, Portland, Ore.

Arch Dermatol. 1978;114(9):1314-1315. doi:10.1001/archderm.1978.01640210009002

• A randomized double-blind study of levamisole hydrochloride therapy in atopic dermatitis is reported. No improvement was noted in any of several assessments, which included patients' subjective impressions; physicians' clinical impressions; comparison of clinical extent and severity scores; and incidence of cutaneous infections or lessening of serum IgE levels. A trend toward improvement was seen in a majority of cases, whether treatment was with a placebo or an active drug. This study emphasizes the need for double-blind techniques for therapeutic trial in the management of patients with atopic dermatitis.

(Arch Dermatol 114:1314-1315, 1978)