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September 1978

Multiple Periorbital Fibrous HistiocytomasA Light and Electron Microscopic Study

Arch Dermatol. 1978;114(9):1345-1347. doi:10.1001/archderm.1978.01640210040011

• Recurrent, bilateral, multiple, periorbital fibrous histiocytomas occurred in a 62-year-old woman. There were no associated serum lipid abnormalities. Histologically, the tumor was composed of an admixture of lipid-laden histiocytes and fibroblasts with a variable amount of collagen production. In many areas the fibroblasts were arranged in a storiform pattern. No cytologic evidence of malignancy was observed. Ultrastructural studies of the tumor showed histiocytic cells with a variable amount of lipid in the cytoplasm and fibroblasts with mild to moderate collagen production. Differential diagnosis and histogenesis are discussed.

(Arch Dermatol 114:1345-1347, 1978)