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October 1978

Metastasizing Atypical Fibroxanthoma: Coexistence With Chronic Lymphocytic Leukemia

Author Affiliations

From the Departments of Pathology (Drs Kemp and Stenn), Dermatology (Dr Stenn), Plastic Surgery (Dr Arons), and Therapeutic Radiology (Dr Fischer), Yale University School of Medicine, New Haven, Conn.

Arch Dermatol. 1978;114(10):1533-1535. doi:10.1001/archderm.1978.01640220082023

• Atypical fibroxanthoma (AFX) is one of a group of cutaneous lesions with a malignant histological appearance but a generally benign clinical course. A 79-year-old white man had AFX of the cheek that recurred and metastasized to buccal and cervical lymph nodes three months after initial diagnosis. When careful physical and laboratory examinations were done, the patient was found to have concomitant chronic lymphatic leukemia, "null cell" type. In view of the low incidence of metastasizing AFX and the increased occurrence of tumors in patients with lymphomatous disorders, an important association is suggested. Before establishing the prognosis for patients with pseudomalignancies of the skin, an evaluation of their general health and immunological status should be made.

(Arch Dermatol 114:1533-1535, 1978)

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