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October 1978

Verrucous Carcinoma of the Penis: Successful Treatment With Cryosurgery and Topical Fluorouracil Therapy

Author Affiliations


From the Department of Dermatology, Naval Regional Medical Center, Oakland, Calif.

Arch Dermatol. 1978;114(10):1546-1547. doi:10.1001/archderm.1978.01640220089026

Verrucous carcinoma is an epithelial neoplasm that is characterized by relentless growth, penetration of adjacent tissues, absence of metastases, histologically benign features, and failure to respond to conservative therapy.

The following report describes an excellent cosmetic and functional result that was obtained by cryosurgery and topical fluorouracil therapy to a persistent, recurrent verrucous carcinoma of the glans penis.

Report of a Case  A 51-year-old man had a horny growth on the dorsal glans penis (Fig 1) that had been enlarging during the previous two years.Various treatments in the past included podophyllum resin (podophyllin) initially, then circumcision and local excision of the lesions. Recurrences appeared and were treated with wide excision and grafting. The site of the grafting was rapidly replaced by the lesion noted in Fig 1, and the patient sought treatment at the Oakland Naval Hospital.A large cutaneous horn with an indurated base was present on the