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October 1978

Leser-Trélat Associated With Acute Leukemia

Author Affiliations

Charlottesville, Va

Arch Dermatol. 1978;114(10):1552. doi:10.1001/archderm.1978.01640220093034

To the Editor.—  The sign of Leser-Trélat is just one of a number of cutaneous markers of internal malignancy and refers to the sudden appearance of a large number of seborrheal keratoses in association with the development of cancer.1 Not only does one see an increase in number of keratoses, but preexisting lesions seem to increase in size in just a matter of days. The significance of the association has been questioned because the incidence of cancer as well as seborrheal keratoses is high in the elderly and, generally, it is the older patient who develops this sign.2 However, the clinical situation can develop so dramatically that one must consider that this association of internal malignancy with the appearance of these benign cutaneous lesions is real and statistically significant. We would like to report such a patient who made believers out of skeptics. The majority of patients exhibiting