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October 1978

Autoimmunity and Vitiligo

Author Affiliations

Thessaloniki, Greece

Arch Dermatol. 1978;114(10):1554. doi:10.1001/archderm.1978.01640220095041

To the Editor.—  The autoimmune nature of vitiligo, at least for a certain number of patients, seems to be more and more likely. Previous reports of an increased incidence of organspecific autoantibodies in those patients support this concept.1-4 The theory has been strengthened recently by the detection of a circulating antibody in two patients with vitiligo, alopecia totalis, mucocutaneous candidiasis, and multiple endocrine insufficiencies, using an immunofluorescent complement-fixation test. This antibody was found bound to melanocytes in human skin, nevus cells, and melanoma cells.5We here report our results of a study that aimed to demonstrate the presence of certain organ-specific autoantibodies in patients with vitiligo and the association of this disorder with autoimmune diseases.

Patients and Methods.—  Eighty-five patients (aged 4 to 78 years) with generalized or localized vitiligo were studied during a period of three years. The patients included in this study were selected on the