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November 1978

Increased Sensitivity of Xeroderma Pigmentosum Skin Fibroblasts to Carcinogenic Compounds

Author Affiliations

East Lansing, Mich

Arch Dermatol. 1978;114(11):1716. doi:10.1001/archderm.1978.01640230086030

To the Editor.—  Recently we published an article1 in which we demonstrated that nonmalignant skin fibroblasts derived from patients with xeroderma pigmentosum (XP) exhibit substantially higher frequencies of mutations induced in the cultured cells by exposure to various reactive metabolites of polycyclic aromatic hydrocarbons (PAHs) than do skin fibroblasts from normal persons. We had previously reported that cultured XP cells exhibit abnormally high frequencies of mutations induced by ultraviolet light.2 Since the observed greater susceptibility of these XP cells to induction of mutations by low doses of ultraviolet light or PAH may be causally related to the enhanced cancer prone condition of patients with XP, our results suggest that patients with XP should be protected not only from sunlight, as is now common practice, but also from PAH.Because PAHs result from many industrial processes, particularly the burning of coal, from household practices such as charcoal broiling of

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