• The effects of orally administered zinc sulfate in 52 patients with mild to moderate acne vulgaris were compared to those of a placebo capsule. The numbers of comedones, papules, pustules, infiltrates, and cysts were counted at each visit over a 12-week period. Forty patients completed the study. Zinc appeared to have a somewhat beneficial effect on pustules but not on comedones, papules, infiltrates, or cysts. Fourteen patients (50%) in the zinc group had side effects of nausea, vomiting, or diarrhea. Six patients (21%) in the zinc group could not tolerate the nausea and withdrew from the study.
(Arch Dermatol 114:1776-1778, 1978)
Weimar VM, Puhl SC, Smith WH, tenBroeke JE. Zinc Sulfate in Acne Vulgaris. Arch Dermatol. 1978;114(12):1776–1778. doi:10.1001/archderm.1978.01640240018005