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December 1978

Progressive Interstitial Lung Disease From Prolonged Methotrexate Therapy

Author Affiliations

From the Division of Pulmonary Sciences, Department of Medicine, University of Colorado Medical Center, Denver (Dr Kaplan), and the Rose Medical Center, Denver (Dr Waite).

Arch Dermatol. 1978;114(12):1800-1802. doi:10.1001/archderm.1978.01640240042014

• Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years. Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane. Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy. Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.

(Arch Dermatol 114:1800-1802, 1978)