[Skip to Content]
[Skip to Content Landing]
December 1978

Hyperkeratosis of Nipple and Areola

Author Affiliations

From the Department of Dermatology, Roswell Park Memorial Institute, Buffalo, NY.

Arch Dermatol. 1978;114(12):1844-1845. doi:10.1001/archderm.1978.01640240074023

Hyperkeratosis of the nipple and areola is said to be rare. Mehregan and Rahbari presented two patients with it and reviewed the 13 other reported cases in the world literature.1 They state that this eruption may occur in patients with ichthyosis or it may represent an epidermal nevus, with the latter form usually bilateral and in young women of childbearing age. They further observe that the histologic changes in the nevoid form "resemble either a papillomatous nevus or acanthosis nigricans." Two additional patients under my care also have an impressive bilateral hyperkeratosis of the nipple and areola, one of whom will be reported here in detail.

Report of a Case  A 66-year-old man was examined in September 1977 with a one-year history of bilateral thickening and hyperpigmentation of his nipples and areolae (Fig 1). In June 1971 he underwent a transurethral resection of the prostate and bilateral orchiectomy for