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December 1978

The Proposed Use of H-Receptor Antagonists in Urticaria and Atopic Dermatitis

Author Affiliations

Oakland, Calif

Arch Dermatol. 1978;114(12):1855-1856. doi:10.1001/archderm.1978.01640240079031

To the Editor.—  Over the past few years, it has been learned that H2-receptor sites exist on peripheral vascular walls and on the surface of lymphocytes (possibly polymorphonuclear leukocytes and macrophages as well). Grennan et al demonstrated effective H2-receptor blockade of xenon clearance from histamine-treated canine diarthrodial joints, a model providing indirect measure of synovial perfusion.1 Fermont et al found in human skin that pyrilamine (an H1-antagonist) and metiamide (an H2-antagonist) provided significantly greater suppression of histamineinduced flares than mepyramine alone.2Histamine uptake by tuberculinsensitized lymphocytes could be blocked by metiamide, suggesting H2-receptor sites on these cells.3 Histamine inhibition of T-lymphocyte mediated functions could be effectively blocked with H2-antagonists.4 Cimetidine enhancement of delayed hypersensitivity responses in skin has been shown.5Based on the above data, H2-antagonists may be expected to have

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