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January 1979

Cutaneous Histologic Features in Ehlers-Danlos SyndromeStudy of 21 Patients

Arch Dermatol. 1979;115(1):40-42. doi:10.1001/archderm.1979.04010010012004

Skin biopsy specimens from 21 patients with Ehlers-Danlos syndrome (EDS) were compared with controls. With two exceptions, the appearance of the dermal collagen and elastic tissue as seen in the two groups was indistinguishable. One example of type 4 EDS contained a dermis composed of fibers that resembled actinically damaged elastic tissue. The single example of type 6 EDS contained particularly thin collagen fibers. The dermal thickness of specimens of EDS was similar to that of controls, although the abnormal-appearing specimen of type 4 EDS was also abnormally thin. Since the other two biopsy specimens of type 4 appeared to be within the range of normal, there may be heterogeneity in this form of EDS.

(Arch Dermatol 115:40-42, 1979)