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January 1979

Systemic Lupus Erythematosus: Association With Psoralen-Ultraviolet-A Treatment of Psoriasis

Author Affiliations

From the Rheumatology Division (Drs Eyanson and Brandt) and the Dermatology Department (Drs Greist and Skinner), Indiana University School of Medicine, Indianapolis.

Arch Dermatol. 1979;115(1):54-56. doi:10.1001/archderm.1979.04010010026008

Systemic lupus erythematosus (SLE) developed in a 23-year-old woman with psoriasis during treatment with psoralen-ultraviolet-A (PUVA). The connective tissue disease was characterized by an erythematous rash, hair loss, nephritis, splenomegaly, seizures, and coma. Serum antinuclear antibodies were present in high titer, and hypocomplementemia developed. Antibodies to native or ultraviolet-irradiated DNA were not demonstrated. While the association of psoriasis and lupus may have been fortuitous, the temporal relationships suggest that PUVA treatment in this case may have been of pathogenetic importance in the development of the connective tissue disease.

(Arch Dermatol 115:54-56, 1979)

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