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January 1979

HLA Antigens in Bullous Pemphigoid Among Japanese

Author Affiliations

From the Departments of Dermatology (Dr Hashimoto) and First Surgery (Drs Nakata, Matsuyama, and Mori), University of Osaka (Japan) School of Medicine, and the Department of Dermatology (Dr Miki), University of Ehime School of Medicine, Shigenobucho, Ehime, Japan.

Arch Dermatol. 1979;115(1):96-97. doi:10.1001/archderm.1979.04010010064020

Bullous pemphigoid (BP) is considered an autoimmune bullous disease because circulating anti-basement membrane (BMZ) antibodies were demonstrated in cases of BP.1 Since the HLA-A and B loci are genetically linked with certain immuneresponse genes and immune-response genes may in some way be involved in the production of antibodies, a genetic disequilibrium and HLA frequencies among patients with BP might be anticipated.

In the present study, the incidence of HLA antigens in BP among Japanese was examined to see the linkage with the immune-response gene.

Subjects and Methods  Forty-one (19 male and 22 female) genetically unrelated patients with BP were subjected to HLA typing. The result was compared with that from 130 unrelated healthy blood donors. The blood samples were obtained from patients with BP who visited the Osaka University Hospital or other dermatological institutions in Japan. Control blood samples were collected from the blood donors of the Osaka University

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