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January 1979

Experimental Cutaneous Candidiasis in Rodents

Author Affiliations

Chapel Hill, NC

Arch Dermatol. 1979;115(1):107. doi:10.1001/archderm.1979.04010010073030

To the Editor.—  In a recent publication in the April 1978 Archives (114:539-543), entitled "Experimental Cutaneous Candidiasis in Rodents," Drs Ray and Wuepper investigated the role of the stratum corneum as a defensive barrier to skin invasion by Candida sp and the necessity of an intact complement pathway in the polymorphonuclear leukocyte inflammatory response to Candida, which had penetrated the barrier.The authors concluded from their studies that the interaction of Candida organisms with host complement in vivo resulted in the production of complement-derived chemotactic factors, C3a, C5a, and C567 complex. These factors attracted neutrophils to the sites where organisms penetrated the epidermis and, thus, limited the invasiveness of the yeast.That their conclusion seems justified is based on their work in a previous in vitro study,1 which demonstrated that Candida sp may activate the alternative complement pathway in serum to produce factors chemoattractant for neutrophils that are studied

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