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February 1979

Cell-Mediated Immunity In Vitro in Atopic Dermatitis

Author Affiliations

From the Departments of Basic and Clinical Immunology and Microbiology (Drs Horsmanheimo and Fudenberg), Medicine (Dr Banov), and Pathology (Dr Ainsworth), School of Medicine, University of South Carolina, Charleston, and the Department of Dermatology, University of Kuopio, Finland (Dr M. Horsmanheimo).

Arch Dermatol. 1979;115(2):161-164. doi:10.1001/archderm.1979.04010020007003

The function of T cells in atopic dermatitis was studied by leukocyte migration agarose and lymphocyte transformation tests. We found that phytohemagglutinin (PHA)- and PPD-induced release of leukocyte migration inhibition factor (LIF) from lymphocytes is significantly decreased (P <.001) in patients with atopic dermatitis as compared with healthy controls. Blastogenic response of lymphocytes induced by PPD was also decreased in atopic patients as compared with controls (P <.01). No differences were found in spontaneous blastogenesis or in blastogenic response of lymphocytes in vitro to PHA, concanavalin A (ConA), or streptokinase-streptodornase (SK-SD) between patients with atopic dermatitis and controls.

(Arch Dermatol 115:161-164, 1979)

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