Twelve men with severe and long-standing atopic eczema were admitted to a double-blind trial to establish the effects of trimeprazine tartrate, trimipramine maleate, and placebo on nocturnal scratching. Neither of the drugs altered the likelihood of a scratching bout beginning in wakefulness or in any stage of sleep. However, both drugs, especially trimipramine, made sleep less broken, and the reduced time spent in stage 1 of sleep accounted for a modest reduction in the overall amount of scratching during the night.
(Arch Dermatol 115:313-315, 1979)
Savin JA, Paterson WD, Adam K, Oswald I. Effects of Trimeprazine and Trimipramine on Nocturnal Scratching in Patients With Atopic Eczema. Arch Dermatol. 1979;115(3):313–315. doi:10.1001/archderm.1979.04010030021008