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March 1979

Bullous Eruption of Diabetes Mellitus

Author Affiliations

From the Division of Biological Sciences, University of Chicago (Dr Bernstein), and the Section of Dermatology, Department of Medicine, Pritzker School of Medicine, Chicago (Drs Bernstein, Medenica, Soltani, and Griem).

Arch Dermatol. 1979;115(3):324-325. doi:10.1001/archderm.1979.04010030032012

Bullous eruption of diabetes is a cutaneous sign of diabetes mellitus. Patients with this disorder manifest a sudden onset of intraepidermal or subepidermal bullae, which are primarily confined to the extremities and heal within several weeks without scarring. Our patient had severe diabetes and experienced two episodes of bullae associated with intense, ultraviolet light exposure. Negative immunofluorescence, early disappearance of anchoring filaments and half-desmosomes between cell membrane and basal lamina, and the absence of urinary uroporphyrins separate this entity from certain similarappearing conditions. Cation imbalance, precipitated by renal failure, could be a possible causal factor.

(Arch Dermatol 115:324-325, 1979)

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