Monoclonal gammopathies and other abnormalities of immunoglobulin production may characterize or frequently be associated with B-cell lymphoproliferative disorders. We describe a patient with a T-cell cutaneous lymphoma, expressed clinically as Sézary's syndrome, in association with an immunoglobulin A type kappa M-component monoclonal gammopathy. No evidence for the coincident presence of a malignant plasma dyscrasia was found. This clinical association may lend clinical support to the concept that Sézary's syndrome is a T-helper-cell malignant proliferation. A colonic carcinoma was also present, possibly representing a second manifestation of a functionally abnormal cellular immune system.
(Arch Dermatol 115:326-328, 1979)
Joyner MV, Cassuto J, Dujardin P, Barety M, Duplay H, Audoly P. Cutaneous T-Cell Lymphoma in Association With a Monoclonal Gammopathy. Arch Dermatol. 1979;115(3):326–328. doi:10.1001/archderm.1979.04010030034013
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: