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March 1979

Histoplasmosis of Skin and Lymph Nodes and Chronic Lymphocytic Leukemia

Author Affiliations

From the Departments of Pathology (Drs Johnston and Tang) and Medicine (Hematology) (Dr Jiji), University of Maryland School of Medicine, Baltimore.

Arch Dermatol. 1979;115(3):336-337. doi:10.1001/archderm.1979.04010030044017

Nodular skin and cervical lymph node lesions of histoplasmosis, unassociated with systemic symptoms of the infection, developed in a 63-year-old man with untreated chronic lymphocytic leukemia. The histologic patterns in both the skin and lymph node were those of a lymphoproliferative disorder, but Histoplasma organisms were found within a few scattered histiocytes after a careful search. The subtle clinical and pathologic presentation might lead one to overlook the organisms and to believe that the leukemic process had progressed, resulting in potentially dangerous systemic involvement of histoplasmosis and unnecessary chemotherapy for his leukemic process. Complete remission of histoplasmosis was obtained with amphotericin B therapy.

(Arch Dermatol 115:336-337, 1979)