Exfoliative erythroderma, characterized clinically by universal erythema and desquamation of skin, is a serious dermatologic condition. Drug allergy is the cause of about 10% of the cases of exfoliative erythroderma,1,2 and such cases are clinically and histologically similar to erythroderma due to other causes.
Ethylenediamine is a common industrial agent used as a dibasic stabilizer in many dyes, fungicides, synthetic waxes, insecticides, resins, and asphalt wetting agents. Medical sources of ethylenediamine include aminophylline (a combination of 80% theophylline and 15% ethylenediamine hydrochloride), a cream composed of triamcinolone acetonide, neomycin sulfate, gramicidin, and nystatin (Mycolog), and various ophthalmic solutions in which edetic acid is utilized as a preservative. Ethylenediamine has been demonstrated to be a fairly potent sensitizer and inducer of contact dermatitis.3-7 Provost and Jillson5 found that systemically administered aminophylline could lead to exacerbations of patchy eczematous eruption in patients with ethylenediamine sensitivity induced by Mycolog cream.
Bernstein JE, Lorincz AL. Ethylenediamine-Induced Exfoliative Erythroderma. Arch Dermatol. 1979;115(3):360–361. doi:https://doi.org/10.1001/archderm.1979.04010030062024
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