Focal acantholytic dyskeratosis is an abnormal cutaneous histologic pattern characterized by suprabasilar clefts with corps ronds and/or grains. These changes are caused by dissociation of intercellular bridges and aberrant keratinization. Once thought to be specific for Darier's disease, these histologic changes may be encountered in a variety of skin diseases. We report a case of pityriasis rosea in which prominent acantholytic dyskeratosis was noted in biopsy material.
Report of a Case
The condition of a 39-year-old woman was evaluated by our consultation service for an eruption involving the trunk and upper and lower extremities; the face, palms, soles, and mucous membranes were spared. Individual lesions were succulent, red papules (3 mm to 2 cm) with fine superficial scaling. All lesions were clearly oriented along body folds and lines of cleavage (Fig 1). Mineral oil preparations for scabies and potassium hydroxide mounts for fungi were negative.Results of all laboratory tests
Stern JK, Wolf JE, Rosen T. Focal Acantholytic Dyskeratosis in Pityriasis Rosea. Arch Dermatol. 1979;115(4):497. doi:10.1001/archderm.1979.04010040075023
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: