[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
May 1979

Wells' Syndrome: Recurrent Granulomatous Dermatitis With Eosinophilia

Author Affiliations

From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Dermatol. 1979;115(5):611-613. doi:10.1001/archderm.1979.04010050045016

Two cases of granulomatous dermatitis with eosinophilia (Wells' syndrome) are reported. With Wells' original four cases, these two cases define a distinctive dermatosis with onset as cellulitis and formation of solid edema and either final spontaneous resolution or resolution with steroid therapy. Microscopic study showed diffuse tissue eosinophilia and fibrinoid flame figures, evolution of associated focal necrobiosis, and formation of focal microgranulomas associated with eosinophils. Biopsy of muscle and fascia showed comparable fasciitis and eosinophilic myositis. Immunofluorescence in one case disclosed fibrin in the dermis and IgM, IgA, and C3 in the blood vessels of the muscle. Recurrences of the lesions often appeared to be related to drug administration or surgery.

(Arch Dermatol 115:611-613, 1979)