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May 1979

Generalized Connective Tissue Nevi and Ichthyosis in Down's Syndrome

Author Affiliations

From the Division of Dermatology, Affiliated Hospitals of Albert Einstein College of Medicine, Montefiore Hospital Medical Center; and Bronx Municipal Hospital Center.; Dr Levine is now with the University of Arizona Medical Center, Tucson.

Arch Dermatol. 1979;115(5):623-624. doi:10.1001/archderm.1979.04010050053019

The first description of a localized connective tissue nevus with a decreased amount of elastic tissue is credited to Lewandowsky in 1921. Various authors designated these localized hamartomas as nevus anelasticus according to the histologic presentation of the nevus. Sachs1 reported a generalized process that developed after furunculosis and Loewenthal2 described a case in which the lesions became generalized over a ten-year period. We report a case of generalized connective tissue nevi with a decrease in elastic tissue in a patient with Down's syndrome.

Report of a Case  A 47-year-old man who had Down's syndrome was admitted to Bronx Municipal Medical Center, New York, for treatment of sepsis. His family related a history of crops of boils that appeared approximately ten years ago. After draining a whitish material, there were residual nodules. Simultaneously, a "mossy appearance" of the skin occurred at the periphery of the nodules. There was no

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