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May 1979

Topical Tetracycline in the Treatment of Perioral Dermatitis

Author Affiliations

Salt Lake City

Arch Dermatol. 1979;115(5):637. doi:10.1001/archderm.1979.04010050061030

To the Editor.—  It has been reported that a new topical tetracycline preparation is useful in the treatment of acne vulgaris.1 Serum levels of tetracycline were not detected in 35 of 36 acne patients who had used the preparation for a minimum of six weeks. In one case the level was detected at the lower detectable limit of 0.1 μg/mL. On the other hand, patients taking oral tetracycline averaged serum levels of 1.5 μg/mL (Proctor and Gamble Co, Cincinnati, personal communication, December 1978).Because perioral dermatitis is so common in young women of childbearing age, and since tetracycline is so effective in controlling this disease, a study was carried out (1) to test the efficacy of this topical tetracycline in perioral dermatitis, and (2) to determine serum levels of tetracycline in pregnant subjects thus treated.From Aug 1, 1978, to Dec 1, 1978, a total of 30 patients with

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