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To the Editor.—
We read with interest the article of Roth et al (Archives 114:591-592, 1978) entitled "Hereditary Painful Callosities," concerning an autosomal dominant genodermatosis that is characterized by painful callosities developing over pressure points. We do not think that this genodermatotis is uncommon; in France, we often observe such features, which we named "keratodermie palmo-plantaire disséminée type Brauer" and/or "Buschke-Fisher."Last year, we used aromatic tretinoin for treatment of three cases of typical hereditary painful callosities (75 mg/day taken orally). In all three cases, a dramatic improvement was obtained within seven days; the pain disappeared entirely and the patients were able to walk again without any pain. Then the per-day dose was diminished to 50 mg without reappearance of the pain. This dose has been used for six months with no problem. This easy treatment seems to us the best one to relieve but not to definitively cure this
Dupre A, Bonafe J, Christol B. Treatment of Hereditary Painful Callosities With Tretinoin. Arch Dermatol. 1979;115(5):638–639. doi:10.1001/archderm.1979.04010050062034
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