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May 1979

The Dropout Patient-Reply

Author Affiliations

Portland, Ore

Port Washington, NY

Arch Dermatol. 1979;115(5):639. doi:10.1001/archderm.1979.04010050063036

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In Reply.—  Dr Cullen's comments are quite appropriate. We should have made note of dropouts but apparently neglected to mention them because they provided no significant information.Eight patients dropped out. Two had been receiving placebo and noted no change. Of the six receiving levamisole, five discontinued because of real or imagined side effects and the sixth showed 10% improvement at three months and then never reappeared. There was absolutely no evidence that the dropouts were those who went into remission.Dr Cullen next questioned why we assess infection in 27 patients when only 26 completed the full six-month study. As we explained, 32 patients completed three months of the study and we were able to monitor presence or absence of infection in 27 of these.

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