In five cases of extramammary Paget's disease (EMPD), the neoplasms were removed under complete microscopical control by means of fixed-tissue chemosurgical technique in one case and freshtissue technique in four cases. In each lesion there were histologically involved areas extending several centimeters into clinically normal-appearing skin. All patients have been free of the disease for periods from four months to nine years. Other authors using conventional surgery have reported a recurrence rate of 44%. Microscopically controlled surgery offers the most reliable method of removing all of the neoplastic tissue EMPD and preserves as much normal tissue as possible.
(Arch Dermatol 115:706-708, 1979)
Mohs FE, Blanchard L. Microscopically Controlled Surgery for Extramammary Paget's Disease. Arch Dermatol. 1979;115(6):706–708. doi:10.1001/archderm.1979.04010060014018