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June 1979

Antibodies Eluted From Lymphoid Cell Membrane: Occurrence in Certain Varieties of Scleroderma

Author Affiliations

From the Departments of Dermatology, Binnengasthuis, Amsterdam (Dr Cormane and Mr Hamerlinck), and the University of Genova, Italy (Dr Nunzi).

Arch Dermatol. 1979;115(6):709-712. doi:10.1001/archderm.1979.04010060017019

By means of acid elution two antibodies could be removed successfully from the circulating lymphocytes of 11 patients with certain varieties of scleroderma. One was specifically directed against nuclear antigen(s) of endothelial cells (NEC) of the dermal blood vessels, and another against nuclear antigen(s) of epidermal basal cells (NBC) of the involved and uninvolved skin of the patients. In two cases of acroscleroderma, the eluates failed to react with either endothelial or basal cells of involved or uninvolved skin. In none of 20 healthy controls involved in this study could an antibody be eluted from the circulating lymphocytes. The aforementioned antibodies do not bind complement in vitro and do occur in the serum of four patients. Circulating antinuclear antibody (speckled type) was detectable in two cases of scleroderma.

(Arch Dermatol 115:709-712, 1979)

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