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June 1979

Topical Tretinoin Therapy and Oral Lichen Planus

Author Affiliations

From the Department of Oral Surgery, Faculty of Odontology (Drs Sloberg and Thilander) and the Department of Dermatology, Faculty of Medicine (Drs Hersle and Mobacken), University of Göteborg, Sweden.

Arch Dermatol. 1979;115(6):716-718. doi:10.1001/archderm.1979.04010060024021

The treatment of severe forms of oral lichen planus is still relatively unsatisfactory. In this controlled study, 0.1% tretinoin in an adhesive base was used in 23 patients. Fifteen other control patients were similarly treated with the vehicle alone. In the tretinoin-treated group, 71% of the atrophic-erosive lesions improved while 29% improved from the vehicle (P<.05). Reticular-plaque lesions improved in 74% from tretinoin and in 15% from the vehicle (P <.001). Irritation from tretinoin occurs and thorough usage information is mandatory.

(Arch Dermatol 115:716-718, 1979).

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