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June 1979

Yellow Nail Syndrome: Possible Association With Malignancy

Author Affiliations

From the Department of Dermatology, Indiana University School of Medicine, Indianapolis (Dr Guin). Dr Elleman is in private practice in Kokomo, Ind.

Arch Dermatol. 1979;115(6):734-735. doi:10.1001/archderm.1979.04010060042027

A dramatic resolution of yellow nail deformity occurred in a 66-year-old man shortly after the removal of a carcinoma of the larynx. Seventeen months later, a productive cough developed and radiologic evidence of bronchiectasis was found. There was no evidence of lymphedema, pleural effusion, sinusitis, or immunologic abnormalities. At least three other patients with a variant of yellow nail syndrome have died of malignancy. Therefore, the resolution of the nail deformity following laryngectomy may not be fortuitous.

(Arch Dermatol 115:734-735, 1979)