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July 1979

Nail Plate-Nail Bed Separation: An Unusual Side Effect of Systemic Fluorouracil Administration

Author Affiliations

From the Medical Oncology Section, Department of Medicine (Dr Katz) and Department of Dermatology (Dr Hansen), Yale University School of Medicine, New Haven, Conn.

Arch Dermatol. 1979;115(7):860-861. doi:10.1001/archderm.1979.04010070036018

A 62-year-old woman with metastatic gastric carcinoma was treated with fluorouracil for her malignant neoplasm. Nail plate-nail bed separation was noted in the fingers and toes after two months of weekly chemotherapy and appeared to be caused by the fluorouracil.

(Arch Dermatol 115:860-861, 1979)