An unusual pattern of zebra-like hyperpigmentation was observed in a black male infant with congenital defects that included an atrial septal defect, dextrocardia, auricular atresia, deafness, and growth retardation. The hyperpigmentation was strikingly linear and symmetrical and followed a dermatomal distribution, with involvement of the trunk and extremities. Results of histological, histochemical, and electron microscopic studies were normal except for an increase in the number of melanocytes in the bands of hyperpigmentation. This pigmentary anomaly appears to be transient and has faded to 50% of its original intensity. A review of the literature has not disclosed any similar cases.
(Arch Dermatol 115:878-881, 1979)
Alimurung FM, Lapenas D, Willis I, Lang P. Zebra-like Hyperpigmentation in an Infant With Multiple Congenital Defects. Arch Dermatol. 1979;115(7):878–881. doi:10.1001/archderm.1979.04010070054026
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.