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August 1979

Benign Mucous Membrane Pemphigoid Associated With Herpes Simplex

Author Affiliations

Tucson, Ariz

Arch Dermatol. 1979;115(8):930. doi:10.1001/archderm.1979.04010080002003

To the Editor.—  This letter is to report the case of a herpes simplex (HS) virus cultured from a lesion of benign mucous membrane pemphigoid (BMMP). I originally presented this case at a meeting of the Tucson Dermatological Society, June 26, 1978.

Report of a Case.—  A 51-year-old man has had constant vesicles of the buccal mucosa, soft palate, and tongue for two years.Examination showed clusters of tense, clear vesicles surrounded by a halo of erythema on his soft palate. The dorsa of his tongue showed clusters of denuded vesicles and scarring.A biopsy specimen of a lesion showed a denuded epidermis and a nonspecific dermal infiltrate. Direct immunofluorescence showed the following results: IgA, negative; IgG, linear 2+ homogenous staining at dermal-epidermal junction; IgM, linear 1 + homogenous staining at DE junction; C3 focal 1+ staining of DE junction; C4, negative; fibrin, negative; and no evidence of antinuclear antibody binding.