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August 1979

Papular Acrodermatitis Associated With Hepatitis B Virus Infection-Reply

Author Affiliations

Pasadena, Calif

Arch Dermatol. 1979;115(8):931. doi:10.1001/archderm.1979.04010080003006

In Reply.—  Claudy et al described three adult patients with acute hepatitis B and the presence of skin lesions similar to those described by Gianotti. However, in the experience of two of us at the liver unit at the University of Southern California School of Medicine (M.J.T. and M.O.), we have not encountered this type of skin eruption in adults who were hospitalized for acute type B hepatitis. Also, PAC has not been observed in individuals with acute type A or with non-A, non-B hepatitis. Therefore, although PAC may be seen in adults with acute type B hepatitis, it must be extremely rare. One difference of interest is that the three patients described by Claudy et al were jaundiced, while virtually all of the children described in the literature, including our patient, were anicteric. Their finding of C3 deposits in the vessel walls suggests that activation of the alternative complement

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