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September 1979

Treatment of Transient Acantholytic Dermatosis

Author Affiliations

Perth, Australia

Arch Dermatol. 1979;115(9):1033-1034. doi:10.1001/archderm.1979.04010090001003

To the Editor.—  Transient acantholytic dermatosis (TAD)1 is becoming an increasingly well-recognized entity. Its cause appears to be associated with actinic radiation, in some cases with acute and in others with cumulative exposure. Despite the varying clinical pictures2 and varying duration3 of this disease, we have found overall that TAD responds well to orally administered vitamin A.Treatment for TAD has been unsatisfactory in the past, unless one resorted to the use of oral corticosteroids.3 Because some patients with Darier's disease respond well to vitamin A, its use was considered in TAD because of the obvious histologic similarities between the diseases.Since this idea was originally suggested, eight patients have been treated with vitamin A, 50,000 units three times a day for up to two weeks. All patients experienced improvement, some in less than two weeks. After initial improvement the dose was adjusted to a maintenance

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