To the Editor.—
We have been using cimetidine in a 55-year-old man with systemic scleroderma of the acrosclerosis type to control symptoms of reflux esophagitis, including substernal pain on recumbency and postprandially, especially prominent on retiring in the evening.Evaluation of the esophagus with fluoroscopy showed a small hiatal hernia, no noticeable reflux, and normal motility. The stomach, duodenal loop, and small bowel appeared normal. The result of the large bowel series also was considered normal.Endoscopy demonstrated a nodular appearance at the distal area of the esophagus. Biopsy specimens were taken from the area to rule out carcinomatous changes; the results were negative.Esophageal motility studies showed normal upper esophageal sphincter and pharyngeal muscle contractions of the distal two thirds of the esophageal body and multiple low-amplitude simultaneous contractions. The lower esophageal sphincter pressure was 9 mm Hg (normal, 15 to 30 mm Hg).The patient was given cimetidine,
Sciallis GF, Levenson H. Cimetidine in Scleroderma. Arch Dermatol. 1979;115(9):1036. doi:https://doi.org/10.1001/archderm.1979.04010090004010
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